A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Making use of single-molecule optical and AFM imaging and force-spectroscopy techniques, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our exploration passions include things like:
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Our get the job done was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You are a Christian. If you could potentially make this type of artificial cell, would you be 1 move closer to God, or would the job of God have diminished considerably again?
Movement-driven rotary motors for instance windmills and h2o wheels drive functional processes in human Culture. While samples of such rotary motors also characteristic prominently in cell biology, their synthetic development for the nanoscale has remained hard. In this article we demonstrate movement-driven rotary motion of a self-organized DNA nanostructure which is docked onto a nanopore in a thin strong-state membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the solid-state nanopore, and subsequently displays a sustained unidirectional rotary movement of up to twenty rev s−one.
Imagine if, as an alternative to utilizing common best-down silicon electronics, transistors could be designed from the bottom up working with single natural and organic molecules since the switching features? This idea, which turned the basis of currently’s area of molecular electronics, initially emerged within the nineteen seventies.
Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
Tests pseudotopological and nontopological designs ceesdekker for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
Mother nature Physics thanks the nameless reviewers for his or her contribution towards the peer evaluate of this work.
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2004, discovery of latest physics in translocation of DNA through nanopores; initially experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of your mechanical Houses of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.